Completely revised and updated, with 24 brand-new chapters, the Third Edition of this definitive reference is a must for all clinicians who treat benign or malignant breast diseases. This edition features two new sections on pathology, biological markers, and staging of breast cancer and adjuvant systemic therapy of primary breast cancer. Other new chapters cover imaging, pathogenesis of breast cancer, special therapeutic problems, and breast cancer in young women.
Treatment-oriented chapters have been reorganized for greater depth of coverage. An up-to-the-minute "late-breaking" page has been added to many chapters just before publication. This edition also includes new full-color pathology illustrations.
Sommario
SECTION I. BREAST ANATOMY AND DEVELOPMENT
Breast Anatomy and Development
Michael P. Osborne
Molecular Mechanisms Regulating Breast Development
Jeffrey M. Rosen
SECTION II. DIAGNOSIS AND MANAGEMENT OF BENIGN BREAST DISEASES
Physical Examination of the Breast
Monica Morrow
Management of the Palpable Breast
David R. Brenin
Management of Disorders of the Ductal System and Infections
J. Michael Dixon and Nigel J. Bundred
Management of Breast Pain
Ian S. Fentiman
Abnormalities of the Breast in Pregnancy and Lactation
Jeanne A. Petrek
Management of Gynecomastia
Glenn D. Braunstein
Pathology of Benign Breast Disorders
Stuart J. Schnitt and James L. Connolly
SECTION III. BREAST IMAGING AND INAGE—
GUIDED BIOPSY TECHNIQUES
Screening for Breast Cancer
Robert A. Smith and Carl J. D’Orsi
Imaging Analysis: Mammography
Mark A. Helvie
Imaging Analysis: Ultrasound
Ellen B. Mendelson
Imaging Analysis: MR
Susan Orel
Imaging: New Techniques
Matthew Freedman
Image-Guided Biopsy of Nonpalpable Breast Lesions
Luz A. Venta
Integrated Management of Image Detected Lesions
Monica Morrow
SECTION IV. EPIDEMIOLOGY AND ASSESSING AND MANAGING RISK
Epidemiology of Breast Cancer
Walter C. Willett
Inherited Genetic Factors and Breast Cancer
Susan M. Domchek and Barbara L. Weber
Newer Techniques of Risk Assessment
Seema A. Khan
Evaluation and Management of Women with a Strong Family History
Claudine Isaacs, Beth N. Peshkin, and Marc Schwartz
Chemoprevention of Breast Cancer: Laboratory Principles
Joan S. Lewis and V. Craig Jordan
Chemoprevention: Chemical Aspects
Priya Rastogi, Shelly Lo, and Victor G. Vogel
SECTION V. PATHOGENESIS OF BREAST CANCER
Genomic Alterations
Joe Gray
Signal Transduction Pathways in Breast Cancer
Gordon Mills
Alterations in the EGF Superfamily in Breast Cancer
Mark Sliwkowski
The Role of Proteomic Analyses in Breast Cancer
Samir Hanash
Microarray Analysis of Human Breast Cancer
Marc J. van de Vijver
The Biology of Breast Tumor Angiogenesis
Stephen B. Fox and Adrian L. Harris
Control of Invasion and Metastasis
Patricia S. Steeg
Regulation of Apoptosis in Human Breast Cancer
Shaomeng Wang
SECTION VI. IN SITU CARCINOMA
Lobular Carcinoma In Situ: Biology and Pathology
Laura G. Fulford, Jorge S. Reis-Filho, and Sunil R. Lakhani
Lobular Carcinoma In Situ: Clinical Management
Lisa A. Newman
Ductal Carcinoma In Situ: Biology and Pathology
Craig Allred
Ductal Carcinoma In Situ and Microinvasive Carcinoma
Monica Morrow
